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2 edition of Determination of the rates of clearance of insoluble compounds of plutonium from the lung. found in the catalog.

Determination of the rates of clearance of insoluble compounds of plutonium from the lung.

Lynda Watts

Determination of the rates of clearance of insoluble compounds of plutonium from the lung.

by Lynda Watts

  • 203 Want to read
  • 21 Currently reading

Published by National Radiological Protection Board in Didcot .
Written in English


Edition Notes

SeriesReports -- 22.
ID Numbers
Open LibraryOL21548003M
ISBN 100859510204

plutonium compounds were also defined based on their rel-ative solubilities. These classifications are used to predict the rates of absorption of plutonium into the bloodstream from pulmonary deposits. We have found previously that underlying disease can dramatically affect the retention of plutonium in . to ignore other compounds that may contribute to the overall corrosion behavior” (Wick ). Indeed, we believe that plutonium oxides other than PuO 2 and compounds other than oxides play a potent role in plutonium corrosion. These compounds appear to be catalysts, causing anomalous corrosion reactions to proceed at enormous rates.

DTPA compounds are defined as investigational drugs that require the advice and concurrence of the. REAC/TS before administration. The REAC/TS may be contacted at: () Treatment of plutonium-contaminated wounds should involve copious washing and irrigation to .   Determination of absorption rates for plutonium nitrate General Methodology The basic premises underlying the extrapolation of rates of respiratory tract (RT) clearance from animals to humans are: clearance from the RT is a competition between particle transport (RT -4 GI) and particle absorption (RT -4 blood).

Wikimedia Commons has media related to Plutonium compounds.: Pages in category "Plutonium compounds" The following 12 pages are in this category, out of 12 total.   Relatively soluble Pu nitrates (uranium reprocessing) correspond to Type M with f r = , relatively insoluble Pu compounds (Pu refining) are referred to Type S with f r = and for highly insoluble Pu forms (Pu metal finishing), Type Super S is used with f r = Cited by: 7.


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Determination of the rates of clearance of insoluble compounds of plutonium from the lung by Lynda Watts Download PDF EPUB FB2

Health Phys. Jul;29(1) Clearance rates of insoluble plutonium compounds from the lung. Watts L. PMID: [PubMed - indexed for MEDLINE]Cited by:   3. Uncertainties on plutonium lung dissolution parameters. For the majority of cases and controls in the study, exposures were primarily to plutonium nitrate and oxide compounds.

For UKAEA facilities, the chemical form of inhaled plutonium was not well defined, and priors were derived based on site specific solubility by: @article{osti_, title = {Problems with detection of intakes of very insoluble plutonium}, author = {Bihl, D E and Lynch, T P and Carbaugh, E H and Sula, M J}, abstractNote = {Several human cases involving inhalation of plutonium oxide at Hanford have shown clearance half-times from the lung that are much longer than those recommended for class Y material in Publication 30 of the.

Effect of time on the determination of the clearance rates of insoluble plutonium oxide. (PMID) Abstract Citations ; BioEntities ; Related Articles ; External Links ; Métivier H, Masse R, Nolibé D, Lafuma J. Health Physics [, 32(5)] Type. The model for Class Y 'relatively insoluble' compounds of plutonium is shown schematically in Fig.

Eighty percent of the initial pulmonary deposition (P0) is cleared via the tracheobronchial compartment. f, = Initial Pulmonary Deposition (Po) = d = d" 1 " ^ ^ Body Fluids (F) f2 = >a= _^ = d _1 Lymph Nodes f3 = 3 = ° 6 9 3 = d" 1 d ^ (U d : K.R.

Heid, J.J. Jech, R.L. Kathren, M.J. Sula. Also, since the dosimetry protocol was agreed, modifications to the HRTM have been recommended 32 and proposals submitted for updated lung solubility parameters for plutonium and uranium compounds. Publication 78 (ICRP ) suggests that the uranium compounds designated as D, W, and Y by ICRP Publication 30 may be directly correlated to F, M, and S under the new lung model.

LUNG SOLUBILITY STUDIES Many studies have been conducted by both in vivo and in vitro methods to report solubility of uranium compounds. Epidemiological studies of the relationship between risk and internal exposure to plutonium are clearly reliant on the dose estimates used.

The International Commission on Radiological Protection (ICRP) is currently reviewing the latest scientific information available on biokinetic models and dosimetry, and it is likely that a number of changes to the existing models will be by:   Abstract. Isotopic ratios of plutonium and uranium in soil samples were investigated, in order to understand the level of contamination with plutonium and uranium released at the accident of Fukushima Daiichi nuclear power by: The discovery of plutonium, its economic and military importance, sources, production, and nuclear properties are reviewed.

The economic aspects of weapons- and reactor-grade plutonium are outlined. Pulmonary clearance rates for inhaled actinide oxides in rat lung The data for clearance of the tourmaline particles from rat lung ( days) in these experiments can be compared with clearance data over similar times from other laboratories where rats have inhaled aerosols of plutonium oxide (puO2) or mixed oxides of plutonium and Cited by: 2.

Absorption of plutonium compounds in the respiratory tract. E Davesne 1,4, F In vitro studies can provide a quick and rough evaluation of the solubility of a compound in simulated lung fluid, Stather J W and Howden S The effect of chemical form on the clearance of plutonium from the respiratory system of the rat Health Phys.

In order to optimise the monitoring of potentially exposed workers, it is desirable to determine specific values of absorption for the compounds handled.

This study derives specific values of absorption rates for different chemical forms of plutonium from in vitro and animal (monkeys, dogs, mice, rats) experiments, and from human contamination Cited by: Plutonium has 15 isotopes with mass numbers ranging from to Only two plutonium isotopes have commercial and military applications and ease of production.

Plutonium (the half-life is years), which is made in nuclear reactors from neptunium, is used to make compact thermoelectric generators; plutonium given to the potential presence of more insoluble compounds whenever bioassay samples are used to determine solubility.

Figure 4 demonstrates this effect. As can be seen, a mixture of solubility class S and M plutonium produces a clearance curve with virtually the. In a recent epidemiological study, Bayesian uncertainties on lung doses have been calculated to determine lung cancer risk from occupational exposures to plutonium.

These calculations used a revised version of the Human Respiratory Tract Model (HRTM) published by the ICRP. In addition to the Bayesian analyses, which give probability distributions of doses, point estimates of doses (single Cited by: Lung Solution 24 IV Calculated Dissolution Rate for Each 20ml Sample DU5 33 V Calculated Dissolution Rate for Each 20 ml Sample DU9 34 VI Test of Hypothesis (Bo=0) for Slopes Obtained from Linear Regressions (Figs.

8 and 9) 38 VII Determination of Average Dissolution Rate and a Percent Confidence Interval on That Average for DU5 and DU9 39Author: Kevin Craig Crist. Plutonium worker dosimetry. Birchall A(1), Puncher M, Harrison J, Riddell A, Bailey MR, Khokryakov V, Romanov S. including more accurate determination of particle transport rates and long-term dissolution for plutonium compounds, a re-evaluation of long-term binding of dissolved plutonium, and further consideration of modeling for plutonium Cited by:   Specific Cases of Interest.- Case 1.

Late Detection of Minor Wound.- Case 2. Plutonium Metal Fragment in Wound.- Case 3. Plutonium Oxide Inhalation from Improperly Adjusted Mask.- Case 4. Lung Burden Unrelated to a Specific Accident and below Detection Limit of Routine Bioassay.- Case 5. Repetitive Depositions of Plutonium Compounds.- Case : Paperback.

{1) lung cancer potential in humans from inhaled insoluble compounds of plutonium {such as Pu02 particles) has been grossly underestimated by such authoritative bodies as the International Commission on Radiological Protection and the British Medical Research Counci I.

other organs, depending on the solubility of the compound. Little plutonium (about %) is absorbed from the gastrointestinal tract after ingestion, and little is absorbed through the skin followingFile Size: 37KB. Specific Cases of Interest.- Case 1. Late Detection of Minor Wound.- Case 2.

Plutonium Metal Fragment in Wound.- Case 3. Plutonium Oxide Inhalation from Improperly Adjusted Mask.- Case 4. Lung Burden Unrelated to a Specific Accident and below Detection Limit of Routine Bioassay.- Case 5.

Repetitive Depositions of Plutonium Compounds.- Case 6.This section lists some binary compounds with halogens (known as halides), oxygen (known as oxides), hydrogen (known as hydrides), and some other compounds of plutonium. For each compound, a formal oxidation number for plutonium is given, but the usefulness of this number is limited for p -block elements in particular.